Science

037: Dr. Sarah Mennenga from NYU Experimental Therapeutics Laboratory on Using Psilocybin to Treat Anxiety and Depression in Cancer Patients by Joe

This is Entheogen. Talk about tools for generating the divine within.

Today is December 18, 2016, and we are discussing the recent publication of studies from NYU and Johns Hopkins showing that psilocybin can reduce anxiety and depression in cancer patients, and we’re pleased to be joined by Dr. Sarah Mennenga from the NYU Experimental Therapeutics Laboratory.

Find the notes and links for this and other episodes at EntheogenShow.com. Sign up to receive an email when we release a new episode. Follow us @EntheogenShow on Twitter and like EntheogenShow on FaceBook. Thanks for listening.

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Topics:

  • We are grateful to be joined by Dr. Sarah Mennenga, Doctor of Neuroscience, NYU Experimental Therapeutics Laboratory

  • NYU and Johns Hopkins just released studies showing that psilocybin can reduce anxiety and depression in cancer patients

  • 80 percent of participants showed significant reduction of anxiety and depression

  • “One theory is that psilocybin interrupts the circuitry of self-absorbed thinking that is so pronounced in depressed people, making way for a mystical experience of selfless unity” i.e. interrupting or disrupting the Default Mode Network?

  • What is the neurological basis for the geometric shapes and auditory effects that characterize the psilocybin experience. What part does suggestibility play in the experience?

  • The “intensity of the mystical experience described by patients correlated with the degree to which their depression and anxiety decreased” – Why is that? What is it about the nature of the psychedelic or mystical experience that does this?

    • Octavian Mihai “saw black smoke rising from my body”

    • Kevin, a participant in the Johns Hopkins study saw “spirals of iridescent spheres that folded in on themselves”. “But you have to approach the session with the right intentions of why you’re doing it. Because you’re going to meet yourself.”

  • Study protocols, and the unique considerations for psychedelic session
    • “seven-hour music playlists.[...] N.Y.U. leaned toward New Age and world music — Brian Eno; sitars; didgeridoos. Johns Hopkins favored Western classical.”

    • Chalice

    • Buddha statue

  • Collaboration among the few institutions doing psychedelic research
  • Criticism from the academic/scientific community?
  • Political concerns; safety concerns around legalization

  • Stigma in the academic community?

  • fMRI scanning during a psychedelic experience?

  • NYU seeking participants in two upcoming studies:

  • NYU seeking $10 million funding for center to study psychedelics

How to Help:

Further Reading:

 

035: MAPS to Move Ahead with Phase 3 MDMA Trials by Joe

F.D.A. Agrees to New Trials for Ecstasy as Relief for PTSD Patients – NY Times, Nov 29, 2016

“It changed my life.”

It allowed me to see my trauma without fear or hesitation and finally process things and move forward." – study participant Ed Thompson

“There is now a clear path ahead to make MDMA a legal medicine for millions of people suffering from PTSD.” – MAPS Bulletin

MAPS needs to raise approximately $25-30 million (of which they’ve already raised more than $10 million) to complete these Phase 3 trials and all associated toxicity and pharmacology studies over the next 5 years. – NY Times

MAPS.org

034: Remastered: Interview with Rick Doblin, Alex Grey & Allyson Grey at Burning Man 2016 by Joe

Do we have a treat for you.

To welcome our new listeners, we present you a re-mastered special edition of the episode we recorded live at Burning Man on August 31, 2016, which features three pioneers and key drivers in the movement to mainstream psychedelic medicine.

Special thanks to Rod for the audio engineering!

Special note for Patreon supporters: you will get a special before-the-show "opening conversation". Check patreon.com/Entheogen.

Burning Man 2016

We had the great pleasure and honor to speak with three pioneers and key drivers in the movement to mainstream psychedelic medicine:

Alex Grey & Allyson Grey, co-founders of CoSM, the Chapel of Sacred Mirrors (CoSM.org).

Rick Doblin, founder and executive director of MAPS, the Multidisciplinary Association for Psychedelic Studies (MAPS.org).

We thank deeply all three of our esteemed guests for their time and generosity of spirit.

We’d also like to thank Dr. Bronner’s ReFOAMation Village for their hospitality and Alex & Allyson for graciously hosting the recording in their RV.

Topics:

  • Alex & Allyson Grey’s take on the state of the movement to mainstream psychedelics

  • Has non-violence slowed our progress?

  • Alex & Allyson’s $2000 fine for cannabis possession upon entering Burning Man

  • Alex mentions Roland Griffiths’ reprisal of Walter Pahnke’s Good Friday Experiment at Johns Hopkins University: Hopkins Scientists Show Hallucinogen In Mushrooms Creates Universal “Mystical” Experience

  • Rick Doblin discusses the improved relationship with Law Enforcement and the Burning Man organization including better integration of the Zendo Project at Burning Man 2016

  • Rick quotes Einstein: “There’s no conflict between science and religion. There’s a conflict between bad science and bad religion.”

  • Rick talks about how he sees psychedelics being integrated into society in 25 years

  • Rick discusses the “beautiful breakup” he had while on MDA

  • Rick compares MDA to MDMA

  • Allyson discusses her personal experiences with MDA and MDMA

  • The idea of patient self-titration

  • Alex, Allyson, and Rick discuss their milestones this year: 20 years since the founding of CoSM and 30 years since the founding of MAPS

  • Rick describes building a handball court at New College of Florida, overlooking the nudist colony where his girlfriend was lifeguarding

  • Rick discusses the first responders and veterans enrolled in the MDMA for PTSD study (“not just for hippies at Burning Man”)

  • Cannabis as a neuroprotective, anti-tumor agent (and it makes you feel better too)

  • Carl Sagan’s friendship with Lester Grinspoon

  • Carl Sagan’s secret use of cannabis for 40 years

  • Psychedelics and schizophrenia

  • Rick’s idea to create a “drug license” system

  • Time to “come out of the psychedelic closet”

  • MAPS organizes Global Psychedelic Dinners to encourage “coming out” about our psychedelic use

  • BuildEntheon.com

 

Thank you so much for listening to Entheogen and for supporting us on Patreon and for telling your friends.

033: Interview with Rick Doblin, Alex Grey & Allyson Grey at Burning Man 2016 by Joe

Thank you so much for listening to Entheogen and for supporting us on Patreon and by telling your friends.

At Burning Man in 2014, we were inspired to create Entheogen (after a talk with Meriana Dinkova). Since then, we’ve released about one-and-a-half episodes per month.

On this, our two-year anniversary since posting the first episode, we are beyond overjoyed to share with you our very first “on location” recording, and the first time we’ve all recorded in person together –

Burning Man 2016.

We had the great pleasure and honor to speak with not one, not just two, but three pioneers and key drivers in the movement to mainstream psychedelic medicine:

Alex Grey & Allyson Grey, co-founders of CoSM, the Chapel of Sacred Mirrors (CoSM.org).

Rick Doblin, founder and executive director of MAPS, the Multidisciplinary Association for Psychedelic Studies (MAPS.org).

We thank deeply all three of our esteemed guests for their time and generosity of spirit.

We’d also like to thank Dr. Bronner’s ReFOAMation Village for their hospitality and Alex & Allyson for graciously hosting the recording in their RV.

Topics:

  • Alex & Allyson Grey’s take on the state of the movement to mainstream psychedelics

  • Has non-violence hamstrung our progress?

  • Alex & Allyson’s $2000 fine for cannabis possession upon entering Burning Man

  • Alex mentions Roland Griffiths’ reprisal of Walter Pahnke’s Good Friday Experiment at Johns Hopkins University: Hopkins Scientists Show Hallucinogen In Mushrooms Creates Universal “Mystical” Experience

  • Rick Doblin discusses the improved relationship with Law Enforcement and the Burning Man organization including better integration of the Zendo Project at Burning Man 2016

  • Rick quotes Einstein: “There’s no conflict between science and religion. There’s a conflict between bad science and bad religion.”

  • Rick talks about how he sees psychedelics being integrated into society in 25 years

  • Rick discusses the “beautiful breakup” he had while on MDA

  • Rick compares MDA to MDMA

  • Allyson discusses her personal experiences with MDA and MDMA

  • Alex, Allyson, and Rick discuss their milestones this year: 20 years since the founding of CoSM and 30 years since the founding of MAPS

  • Rick describes building a handball court at New College of Florida, overlooking the nudist colony where his girlfriend was lifeguarding

  • Rick discusses the first responders and veterans enrolled in the MDMA for PTSD study (“not just for hippies at Burning Man”)

  • Cannabis as a neuroprotective, anti-tumor agent (and it makes you feel better too)

  • Carl Sagan’s friendship with Lester Grinspoon

  • Carl Sagan’s secret use of cannabis for 40 years

  • Psychedelics and schizophrenia

  • Rick’s idea to create a “drug license” system

  • Time to “come out of the psychedelic closet”

  • MAPS organizes Global Psychedelic Dinners to encourage “coming out” about our psychedelic use

  • BuildEntheon.com

 

Update: this episode has been remastered since the original release.

031: Dr. Julie Holland by Joe

This is Entheogen. Talk about tools for generating the divine within.

Today is June 6, 2016, and we are talking with Dr. Julie Holland, psychopharmacologist, psychiatrist, and best-selling author of several books.

Find the notes and links for this and other episodes at EntheogenShow.com. Sign up to receive an email when we release a new episode. Follow us @EntheogenShow on Twitter and like EntheogenShow on FaceBook. Thanks for listening.

Topics:

  • Julie’s origin story: how did she get interested in this area of research

  • Julie took MDMA with Rick Doblin on the last day it was legal: June 30th, 1985

  • “Cancer of Yang” – Jeremy Wolff’s phrase (Julie’s husband)

  • Vaginal administration of cannabis to avoid the liver from edible ingestion, 11-OH-THC

  • Edibles: Julie emphasizes the need to wait two hours before re-evaluating dosage

  • Overmedication of society

    • “Do you ever overeat and then feel bad about it?” Big pharma’s answer: strong, long-lasting amphetamine daily.

  • Medical and Recreational Entheogens

    • “Recreation is therapeutic”

  • THC, CBD and Terpenes

  • Some people don’t want to get high from their medicine.

  • Munchies mitigation tip: don’t start eating.

  • Punishment doesn’t work with addiction

  • Pornography and the “new normal”: no pubic hair vs. “very bushy” 70’s

Julie’s Books: